Anti-CEACAM3 antibody (1-135) (STJ23090)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CEACAM3 (1-135) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CEACAM3 |
| Gene ID | 1084 |
| Uniprot ID | CEAM3_HUMAN |
| Immunogen Region | 1-135 |
| Immunogen Sequence | MGPPSASPHRECIPWQGLLL TASLLNFWNPPTTAKLTIES MPLSVAEGKEVLLLVHNLPQ HLFGYSWYKGERVDGNSLIV GYVIGTQQATPGAAYSGRET IYTNASLLIQNVTQNDIGFY TLQVIKSDLVNEEAT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-135 of human CD66d/CEACAM3 (NP_001806.2). |
Additional Info
| Tissue Specificity | CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. |
| Post Translational Modifications | Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected. |
| Function | Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. |
| Protein Name | Cell Adhesion Molecule Ceacam3Carcinoembryonic Antigen Cgm1Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3Cea Cell Adhesion Molecule 3Cd Antigen Cd66d |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cell Adhesion Molecule Ceacam3 antibodyAnti-Carcinoembryonic Antigen Cgm1 antibodyAnti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 antibodyAnti-Cea Cell Adhesion Molecule 3 antibodyAnti-Cd Antigen Cd66d antibodyAnti-CEACAM3 antibodyAnti-CD66D antibodyAnti-CGM1 antibody |
Information sourced from Uniprot.org