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Anti-CDX2 antibody [SM4953] (STJA0004953)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant protein corresponding to Mouse CDX2
General Information
| Short Description | Mouse monoclonal anti-CDX2 for use in IHC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM4953 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | IHC/IF (H) 1:1500-1:3000 |
| Formulation | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | Cdx2 |
| Gene ID | 12591 |
| Uniprot ID | CDX2_MOUSE |
| Immunogen | Recombinant protein corresponding to Mouse CDX2 |
Additional Info
| Post Translational Modifications | Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-281 reduces transactivation capacity and increases ubiquitin-dependent proteasome degradation. |
| Function | Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA. |
| Protein Name | Homeobox Protein Cdx-2Caudal-Type Homeobox Protein 2 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Cdx-2 antibodyAnti-Caudal-Type Homeobox Protein 2 antibodyAnti-Cdx2 antibodyAnti-Cdx-2 antibody |
Information sourced from Uniprot.org