Anti-CDX2 antibody (100-200) {Biotin} (STJ500499)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
IsotypeIgG
ImmunogenMid-Region epitope synthetic peptide taken within amino acid region 100-200 on human CDX2 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-CDX2 (100-200) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Monkey/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.65 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:4, 000ELISA: 1:4, 000IP: 1:150IHC: 1:100 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | CDX2 |
| Gene ID | 1045 |
| Uniprot ID | CDX2_HUMAN |
| Immunogen | Mid-Region epitope synthetic peptide taken within amino acid region 100-200 on human CDX2 protein. |
| Immunogen Region | 100-200 |
Additional Info
| Tissue Specificity | Detected in small intestine, colon and pancreas. |
| Post Translational Modifications | Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation. |
| Function | Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA. |
| Protein Name | Homeobox Protein Cdx-2Cdx-3Caudal-Type Homeobox Protein 2 |
| Database Links | Reactome: R-HSA-381771 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Cdx-2 antibodyAnti-Cdx-3 antibodyAnti-Caudal-Type Homeobox Protein 2 antibodyAnti-CDX2 antibodyAnti-CDX3 antibody |
Information sourced from Uniprot.org