Anti-CDX2 antibody (1-100) [S3946RM] (STJ11103946)

Name: Anti-CDX2 antibody (1-100) [S3946RM] (STJ11103946)
SKU: STJ11103946
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11103946

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Short Description	Rabbit monoclonal Homeobox Protein Cdx-2 (1-100) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S3946RM
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	CDX2
Gene ID	1045
Uniprot ID	CDX2_HUMAN
Immunogen Region	1-100
Immunogen Sequence	MYVSYLLDKDVSMYPSSVRH SGGLNLAPQNFVSPPQYPDY GGYHVAAAAAAAANLDSAQS PGPSWPAAYGAPLREDWNGY APGGAAAAANAVAHGLNGGS
Specificity	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CDX2 (Q99626 ).

Tissue Specificity	Detected in small intestine, colon and pancreas.
Post Translational Modifications	Ubiquitinated, leading to its degradation by the proteasome. Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation.
Function	Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.
Protein Name	Homeobox Protein Cdx-2 Cdx-3 Caudal-Type Homeobox Protein 2
Database Links	Reactome: R-HSA-381771
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Homeobox Protein Cdx-2 antibody Anti-Cdx-3 antibody Anti-Caudal-Type Homeobox Protein 2 antibody Anti-CDX2 antibody Anti-CDX3 antibody

Information sourced from Uniprot.org