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Anti-CDNF antibody (25-125 aa) [7D6] (STJA0002818)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant human CDNF protein produced using CHO-based proprietary suspension cell line. Purified from cell culture supernatant. Human CDNF
General Information
| Short Description | Mouse monoclonal anti-CDNF (25-125 aa) for use in ELISA, WB and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/IF |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 7D6 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Protein G purification |
| Dilution Range | ELISA (rhCDNF) 0.1 to 0.2 µg/ml; ELISA (rmCDNF) 0.13 to 0.4 µg/ml; WB 0.25 to 1 µg/ml; IF 0.33 to 10 µg/ml; Monoclonal antibody working dilution has to be established practically for each particular antigen and assay format |
| Formulation | PBS pH 7.4, with 0.1% sodium azide |
| Storage Instruction | Store at-20 °C to-70 °C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles as product degradation may result |
Target Information
| Gene Symbol | CDNF |
| Gene ID | 441549 |
| Uniprot ID | CDNF_HUMAN |
| Immunogen | Recombinant human CDNF protein produced using CHO-based proprietary suspension cell line. Purified from cell culture supernatant. Human CDNF |
| Immunogen Region | 25-125 aa |
| Specificity | Human, mouse; others not tested Binds to the N-terminal part of the human CDNF (aa 25-125) |
Additional Info
| Tissue Specificity | Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. |
| Function | Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra. |
| Protein Name | Cerebral Dopamine Neurotrophic FactorArmet-Like Protein 1Conserved Dopamine Neurotrophic Factor |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Cerebral Dopamine Neurotrophic Factor antibodyAnti-Armet-Like Protein 1 antibodyAnti-Conserved Dopamine Neurotrophic Factor antibodyAnti-CDNF antibodyAnti-ARMETL1 antibody |
Information sourced from Uniprot.org