Anti-CDKN2C antibody (1-168) (STJ23082)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CDKN2C/p18-INK4C (1-168) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CDKN2C |
| Gene ID | 1031 |
| Uniprot ID | CDN2C_HUMAN |
| Immunogen Region | 1-168 |
| Immunogen Sequence | MAEPWGNELASAAARGDLEQ LTSLLQNNVNVNAQNGFGRT ALQVMKLGNPEIARRLLLRG ANPDLKDRTGFAVIHDAARA GFLDTLQTLLEFQADVNIED NEGNLPLHLAAKEGHLRVVE FLVKHTASNVGHRNHKGDTA CDLARLYGRNEVVSLMQANG AGGATNLQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human CDKN2C/p18-INK4C (NP_523240.1). |
Additional Info
| Tissue Specificity | Highest levels found in skeletal muscle. Also found in pancreas and heart. |
| Function | Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. |
| Protein Name | Cyclin-Dependent Kinase 4 Inhibitor CCyclin-Dependent Kinase 6 InhibitorP18-Ink4cP18-Ink6 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-2559585Reactome: R-HSA-69231 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 4 Inhibitor C antibodyAnti-Cyclin-Dependent Kinase 6 Inhibitor antibodyAnti-P18-Ink4c antibodyAnti-P18-Ink6 antibodyAnti-CDKN2C antibodyAnti-CDKN6 antibody |
Information sourced from Uniprot.org