Anti-CDKN2B antibody (50-138) [PTR2192] (STJA0006247)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenSynthesized peptide derived from human p15 INK (PTR2192) AA range: 50-138
General Information
| Short Description | Mouse monoclonal anti-Cyclin-dependent kinase 4 inhibitor B (50-138) for use in WB and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PTR2192 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CDKN2B |
| Gene ID | 1030 |
| Uniprot ID | CDN2B_HUMAN |
| Immunogen | Synthesized peptide derived from human p15 INK (PTR2192) AA range: 50-138 |
| Immunogen Region | 50-138 |
| Specificity | This antibody detects endogenous levels of p15 INK (PTR2192) at Human. The antibody was also Predict react with Mouse;Rat |
Additional Info
| Tissue Specificity | Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. |
| Function | Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. |
| Protein Name | Cyclin-Dependent Kinase 4 Inhibitor BMultiple Tumor Suppressor 2Mts-2P14-Ink4bP15-Ink4bP15ink4b |
| Database Links | Reactome: R-HSA-2173796Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-2559585Reactome: R-HSA-69231 |
| Cellular Localisation | CytoplasmAlso Found In The Nucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 4 Inhibitor B antibodyAnti-Multiple Tumor Suppressor 2 antibodyAnti-Mts-2 antibodyAnti-P14-Ink4b antibodyAnti-P15-Ink4b antibodyAnti-P15ink4b antibodyAnti-CDKN2B antibodyAnti-MTS2 antibody |
Information sourced from Uniprot.org