Anti-CDKN2A/p16INK4a antibody [R07-2K1] (STJA0034161)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of mouse CDKN2A/p16INK4a
General Information
| Short Description | Rabbit monoclonal anti-CDKN2A/p16INK4a for use in WB, ICC, IF and IP in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-2K1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | Cdkn2a |
| Gene ID | 12578 |
| Uniprot ID | CDN2A_MOUSE |
| Immunogen | Recombinant protein of mouse CDKN2A/p16INK4a |
Additional Info
| Post Translational Modifications | Phosphorylation seems to increase interaction with CDK4. |
| Function | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. |
| Protein Name | Cyclin-Dependent Kinase Inhibitor 2aCyclin-Dependent Kinase 4 Inhibitor ACdk4iP16-Ink4aP16-Ink4 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase Inhibitor 2a antibodyAnti-Cyclin-Dependent Kinase 4 Inhibitor A antibodyAnti-Cdk4i antibodyAnti-P16-Ink4a antibodyAnti-P16-Ink4 antibodyAnti-Cdkn2a antibodyAnti-P16ink4a antibody |
Information sourced from Uniprot.org