Anti-CDK8 antibody [R03-4H-9] (STJA0033743)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenPeptide
General Information
| Short Description | Rabbit monoclonal anti-CDK8 for use in IHC-P in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-4H-9 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | IHC-P 1:50-1:100 |
| Formulation | Liquid in PBS, Glycerol and BSA |
| Storage Instruction | Store at-20°C. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CDK8 |
| Gene ID | 1024 |
| Uniprot ID | CDK8_HUMAN |
| Immunogen | Peptide |
Additional Info
| Function | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. |
| Protein Name | Cyclin-Dependent Kinase 8Cell Division Protein Kinase 8Mediator Complex Subunit Cdk8Mediator Of Rna Polymerase Ii Transcription Subunit Cdk8Protein Kinase K35 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2122947Reactome: R-HSA-212436Reactome: R-HSA-2173796Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-381340Reactome: R-HSA-9833110Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 8 antibodyAnti-Cell Division Protein Kinase 8 antibodyAnti-Mediator Complex Subunit Cdk8 antibodyAnti-Mediator Of Rna Polymerase Ii Transcription Subunit Cdk8 antibodyAnti-Protein Kinase K35 antibodyAnti-CDK8 antibody |
Information sourced from Uniprot.org