Anti-CDK16 antibody (277-496) (STJ117850)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CDK16 (277-496) antibody for use in IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CDK16 |
| Gene ID | 5127 |
| Uniprot ID | CDK16_HUMAN |
| Immunogen Region | 277-496 |
| Immunogen Sequence | CHRQKVLHRDLKPQNLLINE RGELKLADFGLARAKSIPTK TYSNEVVTLWYRPPDILLGS TDYSTQIDMWGVGCIFYEMA TGRPLFPGSTVEEQLHFIFR ILGTPTEETWPGILSNEEFK TYNYPKYRAEALLSHAPRLD SDGADLLTKLLQFEGRNRIS AEDAMKHPFFLSLGERIHKL PDTTSIFALKEIQLQKEASL RSSSMPDSGRPAFRVVDTEF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 277-496 of human CDK16 (NP_006192.1). |
Additional Info
| Tissue Specificity | Detected in pancreas islets (at protein level). Detected in brain and pancreas. |
| Post Translational Modifications | Phosphorylation of CDK16 is essential for the binding of CCNY, but also essential for the regulation of CDK16 kinase activity. Phosphorylation of CDK16 is essential for the binding of CCNYl1, but also essential for the regulation of CDK16 kinase activity. Ser-146 and Ser-153 are the most critical sites for the binding of CCNYL1 and for modulating CDK16 kinase activity. Phosphorylation at Ser-153 inhibits kinase activity. |
| Function | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). |
| Protein Name | Cyclin-Dependent Kinase 16Cell Division Protein Kinase 16Pctaire-Motif Protein Kinase 1Serine/Threonine-Protein Kinase Pctaire-1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoplasmic VesicleSecretory VesicleCell MembranePeripheral Membrane ProteinCytoplasmic SideSynapseSynaptosomeColocalizes With Insulin In Pancreas IsletsRecruited To The Cell Membrane By Ccny |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 16 antibodyAnti-Cell Division Protein Kinase 16 antibodyAnti-Pctaire-Motif Protein Kinase 1 antibodyAnti-Serine/Threonine-Protein Kinase Pctaire-1 antibodyAnti-CDK16 antibodyAnti-PCTAIRE1 antibodyAnti-PCTK1 antibody |
Information sourced from Uniprot.org