| Post Translational Modifications | Phosphorylation at Thr-893 increases kinase activity. |
| Function | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. |
| Protein Name | Cyclin-Dependent Kinase 12Cdc2-Related Kinase - Arginine/Serine-RichCrkrsCell Division Cycle 2-Related Protein Kinase 7Cdc2-Related Protein Kinase 7Cell Division Protein Kinase 12Hcdk12 |
| Database Links | Reactome: R-HSA-6796648 |
| Cellular Localisation | NucleusNucleus SpeckleColocalized With Nuclear Speckles Throughout Interphase |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 12 antibodyAnti-Cdc2-Related Kinase - Arginine/Serine-Rich antibodyAnti-Crkrs antibodyAnti-Cell Division Cycle 2-Related Protein Kinase 7 antibodyAnti-Cdc2-Related Protein Kinase 7 antibodyAnti-Cell Division Protein Kinase 12 antibodyAnti-Hcdk12 antibodyAnti-CDK12 antibodyAnti-CRK7 antibodyAnti-CRKRS antibodyAnti-KIAA0904 antibody |
Information sourced from Uniprot.org
