• Flow cytometric analysis of PC-2 cells using N-cadherin monoclonal antibody (green) and negative control (purple).
  • Immunohistochemistry analysis of paraffin-embedded human lung cancer (A) , colon cancer (B) , ovarian cancer (C) and mammary cancer (D) with DAB staining using N-cadherin monoclonal antibody.
  • Immunofluorescence analysis of A431 cells using N-cadherin monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.
  • Western blot analysis using N-cadherin monoclonal antibody against A431 (1) , NIH/3T3 (2) , HeLa (3) , C6 (4) and LNCap (5) cell lysate.

Anti-CDH2 antibody [5D5] (STJ98267)

SKU:
STJ98267

£139.00 - £336.00
Current Stock:
Host: Mouse
Applications: IHC/IF/FC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Cadherin-2 is suitable for use in Immunohistochemistry, Immunofluorescence, Flow Cytometry and ELISA research applications.
Clonality: Monoclonal
Clone ID: 5D5
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: IHC 1:200-1:1000
IF 1:200-1:1000
FC 1:200-1:400
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDH2
Gene ID: 1000
Uniprot ID: CADH2_HUMAN
Specificity: N-cadherin Monoclonal Antibody detects endogenous levels of N-cadherin protein.
Immunogen: Purified recombinant fragment of human N-cadherin expressed in E. Coli.
Function Calcium-dependent cell adhesion protein.preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. Required for proper neurite branching. Required for pre- and postsynaptic organization. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Protein Name Cadherin-2
Cdw325
Neural Cadherin
N-Cadherin
Cd Antigen Cd325
Database Links Reactome: R-HSA-381426
Reactome: R-HSA-418990
Reactome: R-HSA-525793
Reactome: R-HSA-8957275
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Sarcolemma
Cell Junction
Cell Surface
Desmosome
Adherens Junction
Colocalizes With Tmem65 At The Intercalated Disk In Cardiomyocytes
Colocalizes With Obscn At The Intercalated Disk And At Sarcolemma In Cardiomyocytes
Alternative Antibody Names Anti-Cadherin-2 antibody
Anti-Cdw325 antibody
Anti-Neural Cadherin antibody
Anti-N-Cadherin antibody
Anti-Cd Antigen Cd325 antibody
Anti-CDH2 antibody
Anti-CDHN antibody
Anti-NCAD antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance