Anti-CDCP1-Isoform 1 antibody (C-Term) (STJ70098)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CDCP1-Isoform 1 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 90kDa band observed in Human Colon lysates (calculated MW of 92.3kDa according to NP_073753.3). Recommended concentration: 1-3Β΅g/ml.An additional band of unknown identity was al |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20Β°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CDCP1 |
| Gene ID | 64866 |
| Uniprot ID | CDCP1_HUMAN |
| Accession Number | NP_073753.3 |
| Immunogen Region | C-Term |
| Immunogen Sequence | PLLNTQEPMEPAE |
| Specificity | This antibody is expected to recognize isoform 1 (NP_073753.3) only. |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5. N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease. |
| Function | May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. |
| Protein Name | Cub Domain-Containing Protein 1Membrane Glycoprotein Gp140Subtractive Immunization M Plus Hep3-Associated 135 Kda ProteinSima135Transmembrane And Associated With Src KinasesCd Antigen Cd318 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Membrane ProteinShedding May Also Lead To A Soluble PeptideIsoform 3: Secreted |
| Alternative Antibody Names | Anti-Cub Domain-Containing Protein 1 antibodyAnti-Membrane Glycoprotein Gp140 antibodyAnti-Subtractive Immunization M Plus Hep3-Associated 135 Kda Protein antibodyAnti-Sima135 antibodyAnti-Transmembrane And Associated With Src Kinases antibodyAnti-Cd Antigen Cd318 antibodyAnti-CDCP1 antibodyAnti-TRASK antibodyAnti-UNQ2486 antibodyAnti-PRO5773 antibody |
Information sourced from Uniprot.org