| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDC6 |
| Gene ID: | 990 |
| Uniprot ID: | CDC6_HUMAN |
| Immunogen Region: | 1-560 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-560 of human Cdc6 (Q99741). |
| Immunogen Sequence: | MPQTRSQAQATISFPKRKLS RALNKAKNSSDAKLEPTNVQ TVTCSPRVKALPLSPRKRLG DDNLCNTPHLPPCSPPKQGK KENGPPHSHTLKGRRLVFDN QLTIKSPSKRELAKVHQNKI LSSVRKSQEITTNSEQRCPL KKESACVRLFKQEGTCYQQA KLVLNTAVPDRLPAREREMD VIRNFLREHICGKKAGSLYL SGAPGTGKTACLSRILQDLK KELKGFKTIMLNCMSLRTA |
| Post Translational Modifications | Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex. |
| Function | Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
| Protein Name | Cell Division Control Protein 6 Homolog Cdc6-Related Protein Cdc18-Related Protein Hscdc18 P62(Cdc6 Hscdc6 |
| Database Links | Reactome: R-HSA-1362277 Reactome: R-HSA-176187 Reactome: R-HSA-68689 Reactome: R-HSA-68867 Reactome: R-HSA-68949 Reactome: R-HSA-68962 Reactome: R-HSA-69017 Reactome: R-HSA-69205 |
| Cellular Localisation | Nucleus Cytoplasm The Protein Is Nuclear In G1 And Cytoplasmic In S-Phase Cells |
| Alternative Antibody Names | Anti-Cell Division Control Protein 6 Homolog antibody Anti-Cdc6-Related Protein antibody Anti-Cdc18-Related Protein antibody Anti-Hscdc18 antibody Anti-P62(Cdc6 antibody Anti-Hscdc6 antibody Anti-CDC6 antibody Anti-CDC18L antibody |
Information sourced from Uniprot.org