• Immunohistochemistryt analysis of paraffin-embedded human smooth muscle, using CDC5L Antibody. The lane on the right is blocked with the CDC5L peptide.
  • Western blot analysis of the lysates from HeLa cells using CDH8 antibody.
  • Western blot analysis of CDC5L Antibody. The lane on the right is blocked with the CDC5L peptide.

Anti-CDC5L antibody (721-770 aa) (STJ92180)

SKU:
STJ92180

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cell division cycle 5-like protein (721-770 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDC5L
Gene ID: 988
Uniprot ID: CDC5L_HUMAN
Immunogen Region: 721-770 aa
Specificity: Cdc5L Polyclonal Antibody detects endogenous levels of Cdc5L protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CDC5L at the amino acid range 721-770
Post Translational Modifications Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8.
Function DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
Protein Name Cell Division Cycle 5-Like Protein
Cdc5-Like Protein
Pombe Cdc5-Related Protein
Database Links Reactome: R-HSA-72163
Cellular Localisation Nucleus
Nucleus Speckle
Cytoplasm
May Shuttle Between Cytoplasm And Nucleus
Alternative Antibody Names Anti-Cell Division Cycle 5-Like Protein antibody
Anti-Cdc5-Like Protein antibody
Anti-Pombe Cdc5-Related Protein antibody
Anti-CDC5L antibody
Anti-KIAA0432 antibody
Anti-PCDC5RP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance