| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDC5L (563-802) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDC5L |
| Gene ID: |
988 |
| Uniprot ID: |
CDC5L_HUMAN |
| Immunogen Region: |
563-802 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 563-802 of human CDC5L (NP_001244.1). |
| Immunogen Sequence: |
PPLTDLQKSEELIKKEMITM LHYDLLHHPYEPSGNKKGKT VGFGTNNSEHITYLEHNPYE KFSKEELKKAQDVLVQEMEV VKQGMSHGELSSEAYNQVWE ECYSQVLYLPGQSRYTRANL ASKKDRIESLEKRLEINRGH MTTEAKRAAKMEKKMKILLG GYQSRAMGLMKQLNDLWDQI EQAHLELRTFEELKKHEDSA IPRRLECLKEDVQRQQEREK ELQHRYADLLLEKETLKSK |
| Tissue Specificity | Ubiquitously expressed in both fetal and adult tissues. |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8. |
| Function | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). |
| Protein Name | Cell Division Cycle 5-Like ProteinCdc5-Like ProteinPombe Cdc5-Related Protein |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmMay Shuttle Between Cytoplasm And Nucleus |
| Alternative Antibody Names | Anti-Cell Division Cycle 5-Like Protein antibodyAnti-Cdc5-Like Protein antibodyAnti-Pombe Cdc5-Related Protein antibodyAnti-CDC5L antibodyAnti-KIAA0432 antibodyAnti-PCDC5RP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
