| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Cell division control protein 42 homolog (80-160 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDC42 |
| Gene ID: | 998 |
| Uniprot ID: | CDC42_HUMAN |
| Immunogen Region: | 80-160 aa |
| Specificity: | CDC42 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 80-160 |
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. |
| Protein Name | Cell Division Control Protein 42 HomologG25k Gtp-Binding Protein |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-182971Reactome: R-HSA-2029482Reactome: R-HSA-389359Reactome: R-HSA-3928662Reactome: R-HSA-418885Reactome: R-HSA-428543Reactome: R-HSA-4420097Reactome: R-HSA-525793Reactome: R-HSA-5625970Reactome: R-HSA-5626467Reactome: R-HSA-5627123Reactome: R-HSA-5663213Reactome: R-HSA-5663220Reactome: R-HSA-5687128Reactome: R-HSA-8950505Reactome: R-HSA-8964616Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013406Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013420Reactome: R-HSA-9013423Reactome: R-HSA-9013424Reactome: R-HSA-9664422Reactome: R-HSA-983231 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleMidbodyCell ProjectionDendriteLocalizes To Spindle During Prometaphase CellsMoves To The Central Spindle As Cells Progressed Through Anaphase To TelophaseLocalizes At The End Of Cytokinesis In The Intercellular Bridge Formed Between Two Daughter CellsIts Localization Is Regulated By The Activities Of Guanine Nucleotide Exchange Factor Ect2 And Gtpase Activating Protein Racgap1Colocalizes With Nek6 In The CentrosomeIn Its Active Gtp-Bound Form Localizes To The Leading Edge Membrane Of Migrating Dendritic Cells |
| Alternative Antibody Names | Anti-Cell Division Control Protein 42 Homolog antibodyAnti-G25k Gtp-Binding Protein antibodyAnti-CDC42 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
