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Anti-CDC20 antibody (81-130 aa) (STJ92156)

Western blot analysis of lysates from Jurkat and HeLa cells, using p55CDC Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of 3T3 cells using Cdc20 Polyclonal Antibody diluted at 1：2000
Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
Western blot analysis of various cells using Cdc20 Polyclonal Antibody diluted at 1：2000

Anti-CDC20 antibody (81-130 aa) (STJ92156)

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STJ92156

£46.00 - £226.00

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cell division cycle protein 20 homolog (81-130 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CDC20
Gene ID:	991
Uniprot ID:	CDC20_HUMAN
Immunogen Region:	81-130 aa
Specificity:	Cdc20 Polyclonal Antibody detects endogenous levels of Cdc20 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human p55CDC at the amino acid range 81-130

Function	Involved in the metaphase/anaphase transition of cell cycle. Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41.
Protein Name	Cell Division Cycle Protein 20 Homolog P55cdc
Database Links	Reactome: R-HSA-141405 Reactome: R-HSA-141430 Reactome: R-HSA-141444 Reactome: R-HSA-174048 Reactome: R-HSA-174113 Reactome: R-HSA-174154 Reactome: R-HSA-174178 Reactome: R-HSA-174184 Reactome: R-HSA-176407 Reactome: R-HSA-176408 Reactome: R-HSA-176409 Reactome: R-HSA-176417 Reactome: R-HSA-179409 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-5663220 Reactome: R-HSA-5689880 Reactome: R-HSA-68877 Reactome: R-HSA-9648025 Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Chromosome Centromere Kinetochore Spindle Pole
Alternative Antibody Names	Anti-Cell Division Cycle Protein 20 Homolog antibody Anti-P55cdc antibody Anti-CDC20 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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