• Anti-CD98 antibody [IPO-T10] (STJ16100143)

Anti-CD98 antibody [IPO-T10] (STJ16100143)

SKU:
STJ16100143

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Host: Mouse
Applications: FC/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD98 is suitable for use in Flow Cytometry and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: IPO-T10
Conjugation: Unconjugated
Isotype: IgMk
Formulation: PBS with 0.02% Sodium Azide.
Purification: Affinity purified from tissue culture.
Concentration: Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range: Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunohistology (1-2 µg/ml for 30 min at RT; an appropriate antigen retrieval method for staining of formalin-fixed tissues has not been established to date).
Storage Instruction: Store for up to 1 year at 2-8°C upon receipt.
Gene Symbol: SLC7A5
Gene ID: 8140
Uniprot ID: LAT1_HUMAN
Immunogen: A BALB/c mouse was immunized with stimulated human PBL. Fusion partner: P3-X63-Ag8.653.
Tissue Specificity Detected in placenta, in the syncytiotrophoblast layer (at protein level). Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2.
Function The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine. The heterodimer with SLC3A2 mediates the uptake of L-DOPA. Functions as an amino acid exchanger. May play a role in the transport of L-DOPA across the blood-brain barrier. May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier.Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane. (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.
Protein Name Large Neutral Amino Acids Transporter Small Subunit 1
4f2 Light Chain
4f2 Lc
4f2lc
Cd98 Light Chain
Integral Membrane Protein E16
E16
L-Type Amino Acid Transporter 1
Hlat1
Solute Carrier Family 7 Member 5
Y+ System Cationic Amino Acid Transporter
Database Links Reactome: R-HSA-210991
Reactome: R-HSA-352230
Reactome: R-HSA-71240
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Lysosome Membrane
Located To The Plasma Membrane By Slc3a2/4f2hc
Localized To The Apical Membrane Of Placental Syncytiotrophoblastic Cells
Recruited To Lysosomes By Laptm4b
Alternative Antibody Names Anti-Large Neutral Amino Acids Transporter Small Subunit 1 antibody
Anti-4f2 Light Chain antibody
Anti-4f2 Lc antibody
Anti-4f2lc antibody
Anti-Cd98 Light Chain antibody
Anti-Integral Membrane Protein E16 antibody
Anti-E16 antibody
Anti-L-Type Amino Acid Transporter 1 antibody
Anti-Hlat1 antibody
Anti-Solute Carrier Family 7 Member 5 antibody
Anti-Y+ System Cationic Amino Acid Transporter antibody
Anti-SLC7A5 antibody
Anti-CD98LC antibody
Anti-LAT1 antibody
Anti-MPE16 antibody

Information sourced from Uniprot.org

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