| Background | Mouse anti Human CD94 antibody, clone DX22 recognizes human Natural killer cells antigen CD94, also known as KLRD1, Killer cell lectin-like receptor, subfamily D, member 1, CD94, KP43 and NK cell receptor. CD94 is a 179 amino acid single pass type II transmembrane glycoprotein with a predicted molecular mass of ~20.5 kDa. There are 3 isoforms of CD94 derived by alternative splicing.CD94 is expressed on natural killer (NK) cells and a subset of T lymphocytes.CD94 is found to associate with NKG2 to form a heterodimer, involved in the inhibition of cell mediated cytotoxicity against cells bearing appropriate MHC class I allotypes.Mouse anti Human CD94 antibody, clone DX22 is reported to inhibit the binding of CD94 to HLA-E (Braud et al. 1998) and HLA-G (Söderström. et al. 1997). |
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