Anti-CD93 antibody [VIMD2] (STJ16103332)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenKG1 cell line
General Information
| Short Description | Mouse monoclonal anti-CD93 for use in WB, ICC, FC, IHC and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/FC/IHC/IP |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | VIMD2 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by protein-A affinity chromatography. |
| Formulation | Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | CD93 |
| Gene ID | 22918 |
| Uniprot ID | C1QR1_HUMAN |
| Immunogen | KG1 cell line |
Additional Info
| Post Translational Modifications | N- and O-glycosylated. Phosphorylated on Tyr-628 and Tyr-644 by SRC.these phosphorylations promote endothelial cell adhesion and migration. |
| Function | Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function. Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function. |
| Protein Name | Complement Component C1q ReceptorC1q/Mbl/Spa ReceptorC1qrC1qr(PC1qrpCdw93Complement Component 1 Q Subcomponent Receptor 1Matrix-Remodeling-Associated Protein 4Cd Antigen Cd93 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Complement Component C1q Receptor antibodyAnti-C1q/Mbl/Spa Receptor antibodyAnti-C1qr antibodyAnti-C1qr(P antibodyAnti-C1qrp antibodyAnti-Cdw93 antibodyAnti-Complement Component 1 Q Subcomponent Receptor 1 antibodyAnti-Matrix-Remodeling-Associated Protein 4 antibodyAnti-Cd Antigen Cd93 antibodyAnti-CD93 antibodyAnti-C1QR1 antibodyAnti-MXRA4 antibody |
Information sourced from Uniprot.org