| Background | This product is a FCM antibody cocktail made up of FITC Anti-Human CD19 [Clone: CB19] (Mouse IgG1, Kappa ) , PE Anti-Human CD56 Antibody [Clone: 5.1H11] (Mouse IgG1, Kappa ) , PE/Cyanine7 Anti-Human CD3 Antibody [Clone: OKT-3] (Mouse IgG2a, Kappa ) and PerCP Anti-Human CD45 Antibody [Clone: HI30] (Mouse IgG1, Kappa ).; CD19 is a single-chain transmembrane glycoprotein expressed on B cells of all stages except plasma cells. It is a common marker for B cells. CD19 is also expressed in follicular dendritic cells. It forms complex with CD21 and CD84, which forms co-receptor with BCR. It takes part in B cell development, activantion and differentiation.; CD56 is also call neural cell adhesion molecule (NCAM) , expressed on neurons, glia and skeletal muscle cells. In hematopoietic cells, CD56 is also expressed on NK cells and NKT cells. CD56 can be used to detect NK cells, Gamma/Delta T cells and activated CD8+ cells.; CD3 is a heterotetrameric protein consisting of a CD3 Gamma, a CD Delta and 2 CD3 Epsilon. It forms complex with TCR. OKT-3 recognize human CD3 Epsilon. Human CD3 is expressed on the surface of T cells and NKT cells.; CD45 is a single-chain type I transmembrane glycoprotein. Except for erythrocytes and platelets, CD45 is expressed on nearly all of the hematopoietic cells with high level. It is a common marker for blood leukocytes. CD45 is a receptor type protein tyrosine phophatase and plays essential roles in B cell and T cells signaling. |
Information sourced from Uniprot.org
