![Anti-CD86/B7-2 nanobody [SAA1279] (STJN000219)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200832/413014/STJN000219-SDS-PAGE-1__40600.1749232531.jpg?c=1 "Anti-CD86/B7-2 nanobody [SAA1279] (STJN000219)")
![Anti-CD86/B7-2 nanobody [SAA1279] (STJN000219)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200832/413014/STJN000219-SDS-PAGE-1__40600.1749232531.jpg?c=1 "Anti-CD86/B7-2 nanobody [SAA1279] (STJN000219)")
Anti-CD86/B7-2 nanobody [SAA1279] (STJN000219)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-T-Lymphocyte Activation antigen Cd86 is suitable for use in ELISA, Flow Cytometry and SPR research applications. |
| Applications | ELISA/FC/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1279 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | CD86 |
| Gene ID | 942 |
| Uniprot ID | CD86_HUMAN |
Additional Info
| Post Translational Modifications | Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. |
| Function | Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. Isoform 2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B. |
| Protein Name | T-Lymphocyte Activation Antigen Cd86Activation B7-2 AntigenB70Bu63Ctla-4 Counter-Receptor B7.2Fun-1Cd Antigen Cd86 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-389356Reactome: R-HSA-389357Reactome: R-HSA-389359Reactome: R-HSA-389513Reactome: R-HSA-6783783Reactome: R-HSA-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Nanobody Names | Anti-T-Lymphocyte Activation Antigen Cd86 nanobodyAnti-Activation B7-2 Antigen nanobodyAnti-B70 nanobodyAnti-Bu63 nanobodyAnti-Ctla-4 Counter-Receptor B7.2 nanobodyAnti-Fun-1 nanobodyAnti-Cd Antigen Cd86 nanobodyAnti-CD86 nanobodyAnti-CD28LG2 nanobody |
Information sourced from Uniprot.org