• LPS-stimulated (3 days) C57BL/6 murine splenocytes were stained with Anti-CD86 antibody (STJA0000095) (filled gray histogram). Unstained splenocytes (empty black histogram) were used as control.

Anti-Cd86 antibody [GL-1] {FITC} (STJA0000095)

SKU:
STJA0000095

£119.50 - £184.50
Current Stock:
Host: Rat
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-T-lymphocyte activation antigen CD86 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: GL-1
Conjugation: FITC
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Cd86
Gene ID: 12524
Uniprot ID: CD86_MOUSE
Tissue Specificity Expressed on activated B-cells.
Post Translational Modifications Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Function Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.
Protein Name T-Lymphocyte Activation Antigen Cd86
Activation B7-2 Antigen
Early T-Cell Costimulatory Molecule 1
Etc-1
Cd Antigen Cd86
Database Links Reactome: R-MMU-1257604
Reactome: -MMU-389356
Reactome: -MMU-389357
Reactome: -MMU-389359
Reactome: -MMU-389513
Reactome: -MMU-6811558
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-T-Lymphocyte Activation Antigen Cd86 antibody
Anti-Activation B7-2 Antigen antibody
Anti-Early T-Cell Costimulatory Molecule 1 antibody
Anti-Etc-1 antibody
Anti-Cd Antigen Cd86 antibody
Anti-Cd86 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance