Anti-CD86 antibody (250-329) {Biotin} (STJ500487)

SKU:
STJ500487-100

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Host: Rabbit
Applications: ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CD86 (250-329) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.50-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:20, 000
ELISA: 1:20, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CD86
Gene ID: 942
Uniprot ID: CD86_HUMAN
Immunogen Region: 250-329
Immunogen: Synthetic peptide taken within amino acid region 250-329 on human CD86 protein.
Tissue Specificity Expressed by activated B-lymphocytes and monocytes.
Post Translational Modifications Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Function Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. Isoform 2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Protein Name T-Lymphocyte Activation Antigen Cd86
Activation B7-2 Antigen
B70
Bu63
Ctla-4 Counter-Receptor B7.2
Fun-1
Cd Antigen Cd86
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-2219530
Reactome: R-HSA-389356
Reactome: R-HSA-389357
Reactome: R-HSA-389359
Reactome: R-HSA-389513
Reactome: R-HSA-6783783
Reactome: R-HSA-6811558
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-T-Lymphocyte Activation Antigen Cd86 antibody
Anti-Activation B7-2 Antigen antibody
Anti-B70 antibody
Anti-Bu63 antibody
Anti-Ctla-4 Counter-Receptor B7.2 antibody
Anti-Fun-1 antibody
Anti-Cd Antigen Cd86 antibody
Anti-CD86 antibody
Anti-CD28LG2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance