Anti-CD85k/LILRB4 antibody [h128-3] (STJA0022379)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Human monoclonal Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4 antibody for use in ELISA and FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | h128-3 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | LILRB4 |
| Gene ID | 11006 |
| Uniprot ID | LIRB4_HUMAN |
Additional Info
| Function | Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance. Receptor for FN1. Receptor for apolipoprotein APOE. Receptor for ALCAM/CD166. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production. This inhibition of monocyte activation occurs at least in part via binding to FN1. Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytotoxic T cells and enhancing the generation of CD8+ T suppressor cells. Induces up-regulation of CD86 on dendritic cells. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4B4Cd85 Antigen-Like Family Member KImmunoglobulin-Like Transcript 3Ilt-3Leukocyte Immunoglobulin-Like Receptor 5Lir-5Monocyte Inhibitory Receptor Hm18Cd Antigen Cd85k |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLigand Binding Leads To Internalization And Translocation To An Antigen-Processing Compartment |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4 antibodyAnti-B4 antibodyAnti-Cd85 Antigen-Like Family Member K antibodyAnti-Immunoglobulin-Like Transcript 3 antibodyAnti-Ilt-3 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 5 antibodyAnti-Lir-5 antibodyAnti-Monocyte Inhibitory Receptor Hm18 antibodyAnti-Cd Antigen Cd85k antibodyAnti-LILRB4 antibodyAnti-ILT3 antibodyAnti-LIR5 antibody |
Information sourced from Uniprot.org