Anti-CD85d/LILRB2 antibody [J19.H1] {APC} (STJA0029624)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationAPC
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | J19.H1 |
| Isotype | IgG1k |
| Conjugation | APC |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | LILRB2 |
| Gene ID | 10288 |
| Uniprot ID | LIRB2_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2Lir-2Leukocyte Immunoglobulin-Like Receptor 2Cd85 Antigen-Like Family Member DImmunoglobulin-Like Transcript 4Ilt-4Monocyte/Macrophage Immunoglobulin-Like Receptor 10Mir-10Cd Antigen Cd85d |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 antibodyAnti-Lir-2 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 2 antibodyAnti-Cd85 Antigen-Like Family Member D antibodyAnti-Immunoglobulin-Like Transcript 4 antibodyAnti-Ilt-4 antibodyAnti-Monocyte/Macrophage Immunoglobulin-Like Receptor 10 antibodyAnti-Mir-10 antibodyAnti-Cd Antigen Cd85d antibodyAnti-LILRB2 antibodyAnti-ILT4 antibodyAnti-LIR2 antibodyAnti-MIR10 antibody |
Information sourced from Uniprot.org