Anti-CD85a/LILRB3 nanobody [SAA2289] (STJN000679)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-His
General Information
| Short Description | Alpaca monoclonal nanobody anti-CD85a/LILRB3 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA2289 |
| Isotype | VHH-His |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Purified by Nickel column. |
| Dilution Range | ELISA: 1:2000-1:20000 |
| Formulation | PBS pH 7.4 |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact with the lab for this information. |
Target Information
| Gene Symbol | LILRB3Uniprot ID=LIRB3_HUMAN" |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2. |
| Function | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3Lir-3Leukocyte Immunoglobulin-Like Receptor 3Cd85 Antigen-Like Family Member AImmunoglobulin-Like Transcript 5Ilt-5Monocyte Inhibitory Receptor Hl9Cd Antigen Cd85a |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Nanobody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 nanobodyAnti-Lir-3 nanobodyAnti-Leukocyte Immunoglobulin-Like Receptor 3 nanobodyAnti-Cd85 Antigen-Like Family Member A nanobodyAnti-Immunoglobulin-Like Transcript 5 nanobodyAnti-Ilt-5 nanobodyAnti-Monocyte Inhibitory Receptor Hl9 nanobodyAnti-Cd Antigen Cd85a nanobodyAnti-LILRB3 nanobodyAnti-ILT5 nanobodyAnti-LIR3 nanobody |
Information sourced from Uniprot.org