Anti-CD72 antibody [3F3] {PE} (STJA0016245)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationPE
IsotypeIgG2bk
General Information
| Short Description | Mouse monoclonal anti-B-Cell Differentiation antigen Cd72 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3F3 |
| Isotype | IgG2bk |
| Conjugation | PE |
| Concentration | 5 Mu L/Tests |
| Purification | Affinity purified |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8Β°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | CD72 |
| Gene ID | 971 |
| Uniprot ID | CD72_HUMAN |
Additional Info
| Tissue Specificity | Pre-B-cells and B-cells but not terminally differentiated plasma cells. |
| Post Translational Modifications | Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1. |
| Function | Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis. |
| Protein Name | B-Cell Differentiation Antigen Cd72Lyb-2Cd Antigen Cd72 |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-B-Cell Differentiation Antigen Cd72 antibodyAnti-Lyb-2 antibodyAnti-Cd Antigen Cd72 antibodyAnti-CD72 antibody |
Information sourced from Uniprot.org