• C57BL/6 murine bone marrow cells were stained with Anti-CD71 antibody (STJA0000484) (filled gray histogram). Unstained bone marrow cells (empty black histogram) were used as control.

Anti-CD71/Tfrc antibody [R17 217.1.3/TIB-219] {FITC} (STJA0000484)

SKU:
STJA0000484

Current Stock:
Host: Rat
Applications: FC
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rat monoclonal antibody anti-Transferrin receptor protein 1 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: R17 217.1.3/TIB-219
Conjugation: FITC
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: Tfrc
Gene ID: 22042
Uniprot ID: TFR1_MOUSE
Post Translational Modifications Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation. Stearoylation does not affect iron uptake. N- and O-glycosylated, phosphorylated and palmitoylated.
Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Upon stimulation, positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2.
Protein Name Transferrin Receptor Protein 1
Tr
Tfr
Tfr1
Trfr
Cd Antigen Cd71
Database Links Reactome: R-MMU-432722
Reactome: -MMU-8856825
Reactome: -MMU-8856828
Reactome: -MMU-8980692
Reactome: -MMU-9013026
Reactome: -MMU-9013106
Reactome: -MMU-9013149
Reactome: -MMU-9013404
Reactome: -MMU-9013406
Reactome: -MMU-9013407
Reactome: -MMU-9013408
Reactome: -MMU-9013423
Reactome: -MMU-917977
Reactome: -MMU-9696270
Reactome: -MMU-9696273
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Melanosome
Alternative Antibody Names Anti-Transferrin Receptor Protein 1 antibody
Anti-Tr antibody
Anti-Tfr antibody
Anti-Tfr1 antibody
Anti-Trfr antibody
Anti-Cd Antigen Cd71 antibody
Anti-Tfrc antibody
Anti-Trfr antibody

Information sourced from Uniprot.org

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