| Short Description : | Rabbit monoclonal CD70 antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FC |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Isotype: | IgG |
| Conjugation: | ABflo® 594 |
| Purification: | Affinity purification |
| Dilution Range: | FC, 5 Mu l per 10^6 cells in 100 Mu l volume |
| Formulation: | PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis) , pH 7.3. |
| Storage Instruction: | Store at 4°C for up to 1 year from the date of receipt. Do not freeze. |
| Gene Symbol: | CD70 |
| Gene ID: | 970 |
| Uniprot ID: | CD70_HUMAN |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Post Translational Modifications | N-glycosylated. |
| Function | Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. |
| Protein Name | Cd70 AntigenCd27 LigandCd27-LTumor Necrosis Factor Ligand Superfamily Member 7Cd Antigen Cd70 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Cd70 Antigen antibodyAnti-Cd27 Ligand antibodyAnti-Cd27-L antibodyAnti-Tumor Necrosis Factor Ligand Superfamily Member 7 antibodyAnti-Cd Antigen Cd70 antibodyAnti-CD70 antibodyAnti-CD27L antibodyAnti-CD27LG antibodyAnti-TNFSF7 antibody |
Information sourced from Uniprot.org