Anti-CD62P antibody [R08-7E1] (STJA0036349)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human CD62P
General Information
| Short Description | Rabbit monoclonal anti-CD62P for use in WB and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-7E1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SELP |
| Gene ID | 6403 |
| Uniprot ID | LYAM3_HUMAN |
| Immunogen | A synthesized peptide derived from human CD62P |
Additional Info
| Tissue Specificity | Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. |
| Function | Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3). |
| Protein Name | P-SelectinCd62 Antigen-Like Family Member PGranule Membrane Protein 140Gmp-140Leukocyte-Endothelial Cell Adhesion Molecule 3Lecam3Platelet Activation Dependent Granule-External Membrane ProteinPadgemCd Antigen Cd62p |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-P-Selectin antibodyAnti-Cd62 Antigen-Like Family Member P antibodyAnti-Granule Membrane Protein 140 antibodyAnti-Gmp-140 antibodyAnti-Leukocyte-Endothelial Cell Adhesion Molecule 3 antibodyAnti-Lecam3 antibodyAnti-Platelet Activation Dependent Granule-External Membrane Protein antibodyAnti-Padgem antibodyAnti-Cd Antigen Cd62p antibodyAnti-SELP antibodyAnti-GMRP antibodyAnti-GRMP antibody |
Information sourced from Uniprot.org