Anti-CD6 antibody [OX-129] {FITC} (STJA0042362)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationFITC
IsotypeIgG2ak
General Information
| Short Description | Rat monoclonal anti-CD6 for use in FC in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Rat |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | OX-129 |
| Isotype | IgG2ak |
| Conjugation | FITC |
| Concentration | 5 Mu L/Test |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | Cd6 |
| Gene ID | 12511 |
| Uniprot ID | CD6_MOUSE |
Additional Info
| Tissue Specificity | Expressed predominantly in thymus, lymph node and spleen. |
| Post Translational Modifications | After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues. Phosphorylated on tyrosine residues in response to stimulation of the TCR complex. Glycosylated. |
| Function | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule.promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. |
| Protein Name | T-Cell Differentiation Antigen Cd6Cd Antigen Cd6 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinDetected At The Immunological SynapseIEAt The Contact Zone Between Antigen-Presenting Dendritic Cells And T-CellsColocalizes With The Tcr/Cd3 Complex At The Immunological Synapse |
| Alternative Antibody Names | Anti-T-Cell Differentiation Antigen Cd6 antibodyAnti-Cd Antigen Cd6 antibodyAnti-Cd6 antibody |
Information sourced from Uniprot.org