Anti-CD6 antibody [MEM-98] (STJ16100729)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenHuman CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone).
General Information
| Short Description | Mouse monoclonal anti-CD6 for use in FC, IP, WB and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IP/WB/IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MEM-98 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Formulation | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | CD6 |
| Gene ID | 923 |
| Uniprot ID | CD6_HUMAN |
| Immunogen | Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone). |
Additional Info
| Tissue Specificity | Detected on thymocytes. Detected on peripheral blood T-cells. Detected on natural killer (NK) cells. Soluble CD6 is detected in blood serum (at protein level). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes. Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. |
| Post Translational Modifications | After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. Glycosylated. |
| Function | Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule.promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. |
| Protein Name | T-Cell Differentiation Antigen Cd6T12Tp120Cd Antigen Cd6 Cleaved Into - Soluble Cd6 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinDetected At The Immunological SynapseIEAt The Contact Zone Between Antigen-Presenting Dendritic Cells And T-CellsColocalizes With The Tcr/Cd3 Complex At The Immunological SynapseSoluble Cd6: SecretedThe Origins Of The Secreted Form Are Not ClearBut It Might Be Created By Proteolytic Shedding Of The Ectodomain |
| Alternative Antibody Names | Anti-T-Cell Differentiation Antigen Cd6 antibodyAnti-T12 antibodyAnti-Tp120 antibodyAnti-Cd Antigen Cd6 Cleaved Into - Soluble Cd6 antibodyAnti-CD6 antibody |
Information sourced from Uniprot.org