Anti-CD59a antibody {ABflo® 488} (STJ11108524)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationABflo® 488
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal CD59a antibody for use in FC in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | ABflo® 488 |
| Purification | Affinity purification |
| Dilution Range | FC, 5 Mu l per 10^6 cells in 100 Mu l volume |
| Formulation | PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis) , pH 7.3. |
| Storage Instruction | Store at 4°C for up to 1 year from the date of receipt. Do not freeze. |
Target Information
| Gene Symbol | Cd59a |
| Gene ID | 12509 |
| Uniprot ID | CD59A_MOUSE |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Expressed in all tissues examined (liver, kidney, spleen, thymus, brain and heart). Low levels in thymus. Also expressed in mononuclear cells, erythrocytes and platelets. Barely detected in neutrophils. |
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Potent inhibitor of the complement membrane attack complex (MAC) action, which protects self-cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. |
| Protein Name | Cd59a GlycoproteinMac-Inhibitory ProteinMac-IpMembrane Attack Complex Inhibition FactorMacifProtectinCd Antigen Cd59 |
| Database Links | |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedLocalizes To The Cell SurfaceSoluble Form Found In A Number Of Tissues |
| Alternative Antibody Names | Anti-Cd59a Glycoprotein antibodyAnti-Mac-Inhibitory Protein antibodyAnti-Mac-Ip antibodyAnti-Membrane Attack Complex Inhibition Factor antibodyAnti-Macif antibodyAnti-Protectin antibodyAnti-Cd Antigen Cd59 antibodyAnti-Cd59a antibodyAnti-Cd59 antibody |
Information sourced from Uniprot.org