| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-CD55 (50-150) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S8MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CD55 |
| Gene ID: |
1604 |
| Uniprot ID: |
DAF_HUMAN |
| Immunogen Region: |
50-150 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CD55 (P08174). |
| Immunogen Sequence: |
EGRTSFPEDTVITYKCEESF VKIPGEKDSVICLKGSQWSD IEEFCNRSCEVPTRLNSASL KQPYITQNYFPVGTVVEYEC RPGYRREPSLSPKLTCLQNL K |
| Tissue Specificity | Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix. |
| Post Translational Modifications | The Ser/Thr-rich domain is heavily O-glycosylated. |
| Function | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. |
| Protein Name | Complement Decay-Accelerating FactorCd Antigen Cd55 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-977606 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell MembraneLipid-AnchorGpi-AnchorIsoform 3: SecretedIsoform 4: SecretedIsoform 5: SecretedIsoform 6: Cell MembraneIsoform 7: Cell Membrane |
| Alternative Antibody Names | Anti-Complement Decay-Accelerating Factor antibodyAnti-Cd Antigen Cd55 antibodyAnti-CD55 antibodyAnti-CR antibodyAnti-DAF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
