| Short Description : | Mouse monoclonal Leukocyte Surface antigen Cd53 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | ELISA |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
| Clonality : | Monoclonal |
| Clone ID : | SAA1593 |
| Isotype: | IgG2a |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | Protein A/G purified from cell culture supernatant |
| Formulation: | 0.01M PBS, pH 7.4. |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
| Gene Symbol: | CD53 |
| Gene ID: | 963 |
| Uniprot ID: | CD53_HUMAN |
| Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Plays a role in the activation of monocytes and B-cells. Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling. Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates. Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression. Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF-alpha and LPS signaling independent of the immune compartment. |
| Protein Name | Leukocyte Surface Antigen Cd53Cell Surface Glycoprotein Cd53Tetraspanin-25Tspan-25Cd Antigen Cd53 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneCell JunctionMembraneMulti-Pass Membrane ProteinSynapseConcentrates In Localized Microdomains Along The Plasma Membrane At The Contact Sites Between Cells Of Fused Myotubes |
| Alternative Antibody Names | Anti-Leukocyte Surface Antigen Cd53 antibodyAnti-Cell Surface Glycoprotein Cd53 antibodyAnti-Tetraspanin-25 antibodyAnti-Tspan-25 antibodyAnti-Cd Antigen Cd53 antibodyAnti-CD53 antibodyAnti-MOX44 antibodyAnti-TSPAN25 antibody |
Information sourced from Uniprot.org
