Anti-CD53 antibody [161-2] (STJ16102739)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
Immunogenstimulated human PBL
General Information
| Short Description | Mouse monoclonal anti-CD53 for use in FC, IHC-F and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IHC-F/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 161-2 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Concentration | 100 Mu g/mL |
| Formulation | PBS with 0.02% sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | CD53 |
| Gene ID | 963 |
| Uniprot ID | CD53_HUMAN |
| Immunogen | stimulated human PBL |
Additional Info
| Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Plays a role in the activation of monocytes and B-cells. Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling. Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates. Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression. Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF-alpha and LPS signaling independent of the immune compartment. |
| Protein Name | Leukocyte Surface Antigen Cd53Cell Surface Glycoprotein Cd53Tetraspanin-25Tspan-25Cd Antigen Cd53 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneCell JunctionMembraneMulti-Pass Membrane ProteinSynapseConcentrates In Localized Microdomains Along The Plasma Membrane At The Contact Sites Between Cells Of Fused Myotubes |
| Alternative Antibody Names | Anti-Leukocyte Surface Antigen Cd53 antibodyAnti-Cell Surface Glycoprotein Cd53 antibodyAnti-Tetraspanin-25 antibodyAnti-Tspan-25 antibodyAnti-Cd Antigen Cd53 antibodyAnti-CD53 antibodyAnti-MOX44 antibodyAnti-TSPAN25 antibody |
Information sourced from Uniprot.org