Anti-CD51/Itgav antibody [RMV-7] {PE} (STJA0002589)

Anti-CD51/Itgav antibody [RMV-7] {PE} (STJA0002589)

⇓ Datasheet ⇓ SDS
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationPE
IsotypeIgG1k
STJA0002589
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General Information

Short DescriptionRat monoclonal anti-Integrin alpha-V for use in FC in Mouse samples. Datasheet included with dilution recommendations, and related reagents.
ApplicationsFC
HostRat
ReactivityMouse
NoteFOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.

Product Properties

ClonalityMonoclonal
Clone IDRMV-7
IsotypeIgG1k
ConjugationPE
Concentration0.2 mg/mL
FormulationPhosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage InstructionStore between 2-8ยฐC and protecting from prolonged exposure to light. Do not freeze this product.

Target Information

Gene SymbolItgav
Gene ID16410
Uniprot IDITAV_MOUSE

Additional Info

Function The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. ITGAV:ITGB3 acts as a receptor for CD40LG. ITGAV:ITGB3 binds to the Lilrb4a/Gp49b receptor and enhances the Lilrb4a-mediated inhibition of mast cell activation. ITGAV:ITGB3 also suppresses marginal zone B cell antibody production through its interaction with Lilrb4a. ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP.
Protein Name Integrin Alpha-V
Vitronectin Receptor Subunit Alpha
Cd Antigen Cd51 Cleaved Into - Integrin Alpha-V Heavy Chain - Integrin Alpha-V Light Chain
Database Links Reactome: R-MMU-1236973
Reactome: -MMU-1566948
Reactome: -MMU-210990
Reactome: -MMU-2129379
Reactome: -MMU-216083
Reactome: -MMU-2173789
Reactome: -MMU-3000170
Reactome: -MMU-3000178
Reactome: -MMU-4420097
Reactome: -MMU-445144
Reactome: -MMU-6798695
Reactome: -MMU-9860927
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Focal Adhesion
Alternative Antibody Names Anti-Integrin Alpha-V antibody
Anti-Vitronectin Receptor Subunit Alpha antibody
Anti-Cd Antigen Cd51 Cleaved Into - Integrin Alpha-V Heavy Chain - Integrin Alpha-V Light Chain antibody
Anti-Itgav antibody

Information sourced from Uniprot.org

Citations

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