![Anti-CD5/Ly-1 antibody [SAA2083] (STJA0021869)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/190585/412637/STJA0021869-SDS-PAGE-1__93037.1749229934.jpg?c=1 "Anti-CD5/Ly-1 antibody [SAA2083] (STJA0021869)")
![Anti-CD5/Ly-1 antibody [SAA2083] (STJA0021869)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/190585/412637/STJA0021869-SDS-PAGE-1__93037.1749229934.jpg?c=1 "Anti-CD5/Ly-1 antibody [SAA2083] (STJA0021869)")
Anti-CD5/Ly-1 antibody [SAA2083] (STJA0021869)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationUnconjugated
IsotypeVHH-hFc
General Information
| Short Description | Human monoclonal T-Cell Surface Glycoprotein Cd5 antibody for use in ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Human |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA2083 |
| Isotype | VHH-hFc |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | Cd5 |
| Gene ID | 12507 |
| Uniprot ID | CD5_MOUSE |
Additional Info
| Function | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production. |
| Protein Name | T-Cell Surface Glycoprotein Cd5Lymphocyte Antigen 1Ly-1Lyt-1Cd Antigen Cd5 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Cell Surface Glycoprotein Cd5 antibodyAnti-Lymphocyte Antigen 1 antibodyAnti-Ly-1 antibodyAnti-Lyt-1 antibodyAnti-Cd Antigen Cd5 antibodyAnti-Cd5 antibodyAnti-Ly-1 antibody |
Information sourced from Uniprot.org