![Anti-CD5 antibody [SM5147] (STJA0005147)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180198/403639/STJA0005147_1__82028.1738950644.png?c=1 "Anti-CD5 antibody [SM5147] (STJA0005147)")
![Anti-CD5 antibody [SM5147] (STJA0005147)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/180198/403639/STJA0005147_1__82028.1738950644.png?c=1 "Anti-CD5 antibody [SM5147] (STJA0005147)")
Anti-CD5 antibody [SM5147] (STJA0005147)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenSynthesized peptide derived from human CD5
General Information
| Short Description | Mouse monoclonal anti-CD5 for use in IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM5147 |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC/IF (H) 1:200-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | CD5 |
| Gene ID | 921 |
| Uniprot ID | CD5_HUMAN |
| Immunogen | Synthesized peptide derived from human CD5 |
Additional Info
| Function | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production. |
| Protein Name | T-Cell Surface Glycoprotein Cd5Lymphocyte Antigen T1/Leu-1Cd Antigen Cd5 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Cell Surface Glycoprotein Cd5 antibodyAnti-Lymphocyte Antigen T1/Leu-1 antibodyAnti-Cd Antigen Cd5 antibodyAnti-CD5 antibodyAnti-LEU1 antibody |
Information sourced from Uniprot.org