![Anti-CD49c/ITGA3 nanobody [SAA1303] (STJN000181)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200794/412976/STJN000181-SDS-PAGE-1__81391.1749232501.jpg?c=1 "Anti-CD49c/ITGA3 nanobody [SAA1303] (STJN000181)")
![Anti-CD49c/ITGA3 nanobody [SAA1303] (STJN000181)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200794/412976/STJN000181-SDS-PAGE-1__81391.1749232501.jpg?c=1 "Anti-CD49c/ITGA3 nanobody [SAA1303] (STJN000181)")
Anti-CD49c/ITGA3 nanobody [SAA1303] (STJN000181)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Integrin Alpha-3 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1303 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | ITGA3 |
| Gene ID | 3675 |
| Uniprot ID | ITA3_HUMAN |
Additional Info
| Post Translational Modifications | Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. |
| Function | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression. |
| Protein Name | Integrin Alpha-3Cd49 Antigen-Like Family Member CFrp-2Galactoprotein B3Gapb3Vla-3 Subunit AlphaCd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-216083Reactome: R-HSA-3000157Reactome: R-HSA-8874081 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLipid-AnchorCell ProjectionInvadopodium MembraneFilopodium MembraneEnriched Preferentially At InvadopodiaCell Membrane Protrusions That Correspond To Sites Of Cell InvasionIn A Collagen-Dependent Manner |
| Alternative Nanobody Names | Anti-Integrin Alpha-3 nanobodyAnti-Cd49 Antigen-Like Family Member C nanobodyAnti-Frp-2 nanobodyAnti-Galactoprotein B3 nanobodyAnti-Gapb3 nanobodyAnti-Vla-3 Subunit Alpha nanobodyAnti-Cd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain nanobodyAnti-ITGA3 nanobodyAnti-MSK18 nanobody |
Information sourced from Uniprot.org