Anti-CD48 antibody {PE-Cy7} (STJ11109096)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationPE-Cy7
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal CD48 antibody for use in FC in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | PE-Cy7 |
| Purification | Affinity purification |
| Dilution Range | FC, 5 Mu l per 10^6 cells in 100 Mu l volume |
| Formulation | PBS with 0.09% Sodium azide, 0.2% BSA, pH7.3. |
| Storage Instruction | Store at 4°C for up to 1 year from the date of receipt. Do not freeze. |
Target Information
| Gene Symbol | Cd48 |
| Gene ID | 12506 |
| Uniprot ID | CD48_MOUSE |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenBcm1 Surface AntigenBlast-1Hm48-1Mrc Ox-45 Surface AntigenSlam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Sgp-60Cd Antigen Cd48 |
| Database Links | Reactome: R-MMU-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftSecreted |
| Alternative Antibody Names | Anti-Cd48 Antigen antibodyAnti-Bcm1 Surface Antigen antibodyAnti-Blast-1 antibodyAnti-Hm48-1 antibodyAnti-Mrc Ox-45 Surface Antigen antibodyAnti-Slam Family Member 2 antibodyAnti-Slamf2 antibodyAnti-Signaling Lymphocytic Activation Molecule 2 antibodyAnti-Sgp-60 antibodyAnti-Cd Antigen Cd48 antibodyAnti-Cd48 antibodyAnti-Bcm-1 antibody |
Information sourced from Uniprot.org