Anti-CD48 antibody [MEM-102] (STJ16100049)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRaji human Burkitt's lymphoma cell line
General Information
| Short Description | Mouse monoclonal anti-CD48 for use in FC, IP, WB and IHC-P in Non-Human Primates and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IP/WB/IHC-P |
| Host | Mouse |
| Reactivity | Non-Human Primates/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MEM-102 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Dilution Range | FC 2 µg/ml-IP-WB to be determined-IHC paraffin to be determined |
| Formulation | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | CD48 |
| Gene ID | 962 |
| Uniprot ID | CD48_HUMAN |
| Immunogen | Raji human Burkitt's lymphoma cell line |
Additional Info
| Tissue Specificity | Widely expressed on all hematopoietic cells. |
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenB-Lymphocyte Activation Marker Blast-1Bcm1 Surface AntigenLeukocyte Antigen Mem-102Slam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Tct.1Cd Antigen Cd48 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftSecreted |
| Alternative Antibody Names | Anti-Cd48 Antigen antibodyAnti-B-Lymphocyte Activation Marker Blast-1 antibodyAnti-Bcm1 Surface Antigen antibodyAnti-Leukocyte Antigen Mem-102 antibodyAnti-Slam Family Member 2 antibodyAnti-Slamf2 antibodyAnti-Signaling Lymphocytic Activation Molecule 2 antibodyAnti-Tct.1 antibodyAnti-Cd Antigen Cd48 antibodyAnti-CD48 antibodyAnti-BCM1 antibodyAnti-BLAST1 antibody |
Information sourced from Uniprot.org