![C57BL/6 murine splenocytes were stained with Anti-Mouse CD48 Monoclonal Antibody (AF647 Conjugated)[Used at 0.2 ยตg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/145081/291747/STJA0000228_1__52124.1631205529.jpg?c=1 "C57BL/6 murine splenocytes were stained with Anti-Mouse CD48 Monoclonal Antibody (AF647 Conjugated)[Used at 0.2 ยตg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.")
![C57BL/6 murine splenocytes were stained with Anti-Mouse CD48 Monoclonal Antibody (AF647 Conjugated)[Used at 0.2 ยตg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/145081/291747/STJA0000228_1__52124.1631205529.jpg?c=1 "C57BL/6 murine splenocytes were stained with Anti-Mouse CD48 Monoclonal Antibody (AF647 Conjugated)[Used at 0.2 ยตg/10<sup>6</sup> cells dilution] (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.")
Anti-Cd48 antibody [HM48-1] {AF647} (STJA0000228)
SPECIFICATIONS
ClonalityMonoclonal
HostArmenian Hamster
ConjugationAF647
IsotypeIgG
General Information
| Short Description | Armenian Hamster monoclonal anti-CD48 antigen for use in FC in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Armenian Hamster |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | HM48-1 |
| Isotype | IgG |
| Conjugation | AF647 |
| Concentration | 0.5 mg/mL |
| Formulation | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction | Store between 2-8ยฐC and protecting from prolonged exposure to light. Do not freeze this product. |
Target Information
| Gene Symbol | Cd48 |
| Gene ID | 12506 |
| Uniprot ID | CD48_MOUSE |
Additional Info
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 AntigenBcm1 Surface AntigenBlast-1Hm48-1Mrc Ox-45 Surface AntigenSlam Family Member 2Slamf2Signaling Lymphocytic Activation Molecule 2Sgp-60Cd Antigen Cd48 |
| Database Links | Reactome: R-MMU-202733 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftSecreted |
| Alternative Antibody Names | Anti-Cd48 Antigen antibodyAnti-Bcm1 Surface Antigen antibodyAnti-Blast-1 antibodyAnti-Hm48-1 antibodyAnti-Mrc Ox-45 Surface Antigen antibodyAnti-Slam Family Member 2 antibodyAnti-Slamf2 antibodyAnti-Signaling Lymphocytic Activation Molecule 2 antibodyAnti-Sgp-60 antibodyAnti-Cd Antigen Cd48 antibodyAnti-Cd48 antibodyAnti-Bcm-1 antibody |
Information sourced from Uniprot.org