| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-CD48 antigen is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 156-4H9 |
| Conjugation: | PE/Cyanine5 |
| Isotype: | IgG1k |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Concentration: | 5 Mu L/Test |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Gene Symbol: | CD48 |
| Gene ID: | 962 |
| Uniprot ID: | CD48_HUMAN |
| Tissue Specificity | Widely expressed on all hematopoietic cells. |
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 Antigen B-Lymphocyte Activation Marker Blast-1 Bcm1 Surface Antigen Leukocyte Antigen Mem-102 Slam Family Member 2 Slamf2 Signaling Lymphocytic Activation Molecule 2 Tct.1 Cd Antigen Cd48 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Membrane Raft Secreted |
| Alternative Antibody Names | Anti-Cd48 Antigen antibody Anti-B-Lymphocyte Activation Marker Blast-1 antibody Anti-Bcm1 Surface Antigen antibody Anti-Leukocyte Antigen Mem-102 antibody Anti-Slam Family Member 2 antibody Anti-Slamf2 antibody Anti-Signaling Lymphocytic Activation Molecule 2 antibody Anti-Tct.1 antibody Anti-Cd Antigen Cd48 antibody Anti-CD48 antibody Anti-BCM1 antibody Anti-BLAST1 antibody |
Information sourced from Uniprot.org
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