• Human peripheral blood lymphocytes were stained with Anti-CD47 antibody (STJA0000380) (filled gray histogram). Unstained lymphocytes (empty black histogram) were used as control.

Anti-CD47 antibody [CC2C6D4] {FITC} (STJA0000380)

SKU:
STJA0000380

Current Stock:
Host: Mouse
Applications: FC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Leukocyte surface antigen CD47 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: CC2C6D4
Conjugation: FITC
Isotype: IgG1k
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: CD47
Gene ID: 961
Uniprot ID: CD47_HUMAN
Tissue Specificity Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
Function Adhesive protein that mediates cell-to-cell interactions. Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling. Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering. Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging. In response to THBS1, negatively modulates wound healing. Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells.
Protein Name Leukocyte Surface Antigen Cd47
Antigenic Surface Determinant Protein Oa3
Integrin-Associated Protein
Iap
Protein Mer6
Cd Antigen Cd47
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-391160
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Leukocyte Surface Antigen Cd47 antibody
Anti-Antigenic Surface Determinant Protein Oa3 antibody
Anti-Integrin-Associated Protein antibody
Anti-Iap antibody
Anti-Protein Mer6 antibody
Anti-Cd Antigen Cd47 antibody
Anti-CD47 antibody
Anti-MER6 antibody

Information sourced from Uniprot.org

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