Anti-CD45RB antibody [MEM-55] (STJ16100086)

SKU:

STJ16100086-01

£393.50

General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Mouse
Applications:	FC/IP/WB/IHC-P
Reactivity:	Non-Human Primates/Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-CD45RB is suitable for use in Flow Cytometry, Immunoprecipitation, Western Blot and Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	MEM-55
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration:	1 mg/mL
Storage Instruction:	Store at 2-8°C upon receipt.

Immunogen:

Human thymocytes and T lymphocytes.

Background

CD45RB is an of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed e.g. in microglia and inflammatory cells.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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