Anti-CD45RA antibody [MB1] {R-PE} (STJA0018327)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationR-PE
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal anti-Receptor-Type Tyrosine-Protein Phosphatase C for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | FOR RESEARCH USE ONLY (RUO). |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MB1 |
| Isotype | IgG1 |
| Conjugation | R-PE |
| Purification | Protein A purification |
| Dilution Range | Please carry out application specific titration to determine the most appropriate dilution ratio. |
| Formulation | PBS with 0.2% BSA, and 0.09% Sodium Azide |
| Storage Instruction | Shipped on gel ice packs. Store at 2-8C on arrival. |
Target Information
| Gene Symbol | PTPRC |
| Gene ID | 5788 |
| Uniprot ID | PTPRC_HUMAN |
Additional Info
| Post Translational Modifications | Heavily N- and O-glycosylated. |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact.CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase CLeukocyte Common AntigenL-CaT200Cd Antigen Cd45 |
| Database Links | Reactome: R-HSA-202427Reactome: R-HSA-416700Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftSynapseColocalized With Dpp4 In Membrane Rafts |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase C antibodyAnti-Leukocyte Common Antigen antibodyAnti-L-Ca antibodyAnti-T200 antibodyAnti-Cd Antigen Cd45 antibodyAnti-PTPRC antibodyAnti-CD45 antibody |
Information sourced from Uniprot.org