Anti-CD45R antibody [IHC536] (STJA0042033)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-CD45R for use in IHC-p in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-p |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | IHC536 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Dilution Range | 1:50-1:200 |
| Formulation | Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1 year. Do not freeze. |
Target Information
| Specificity | Tested and validated on lymph node, tonsil tissue. |
Additional Info
| Background | CD45R, also known as MB1, is an isoform on CD45 that is a member on the protein tyrosine phosphatase (PTPase) family. CD45R is expressed specifically on the surface on hematopoietic cells, and has demonstrated function as a regulator on the antigen and cytokine receptor signaling on B-and T-cells. Given that the antigen is located in the membrane on all B-cells, with the exception on plasma cells and some mature T-cells, Anti-CD45R exhibits specific reactivity with most B-lymphocytes. The use on Anti-CD45R is primarily useful in distinguishing B-cell lymphomas from T-cell lymphomas, with specific reactivity to follicle center cells, mantle cells, some medullary thymocytes, and 80% on B-cell lymphomas. |
Information sourced from Uniprot.org